Our guide to Sunday's Guinness Six Nations clash between Italy and Ireland in Rome includes team news, predictions, statistics and more.
Ireland got their Six Nations bid back on track with victory over Scotland and will expect nothing less in Italy, where they won by 53 points on their last visit.
The hosts showed signs of promise in an opening-round defeat to Scotland and again versus Wales, but this looks their toughest test yet and they're priced to suffer a third defeat in as many matches.
The match, which takes place in Rome, will start at 1500 GMT on Sunday February 24 and will be screened live on ITV 1.
Italy: J Hayward (Benetton); E Padovani (Zebre), M Campagnaro (Wasps), L Morisi (Benetton), A Esposito (Benetton); T Allan (Benetton), T Tebaldi (Benetton); A Lovotti (Zebre), L Ghiraldini (Toulouse, capt), S Ferrari (Benetton), F Ruzza (Benetton), D Budd (Benetton), J Tuivaiti (Zebre), M Mbanda (Zebre), A Steyn (Benetton). Replacements: L Bigi (Benetton), C Traore (Benetton), T Pasquali (Benetton), D Sisi (Zebre), A Zanni (Benetton), G Palazzani (Zebre), I McKinley (Benetton), T Castello (Zebre).
Ireland team: D Kilcoyne (Munster), S Cronin, T Furlong (both Leinster), U Dillane, Q Roux (both Connacht), P O'Mahony (Munster, capt), S O'Brien (Leinster), J Murphy (Ulster), C Murray (Munster), J Sexton (Leinster), J Stockdale (Ulster), B Aki (Connacht), C Farrell, K Earls (both Munster), R Kearney (Leinster). Replacements: N Scannell (Munster), J McGrath (Leinster), John Ryan (Munster), I Henderson (Ulster), J Van Der Flier (Leinster), J Cooney (Ulster), J Carty (Connacht), A Conway (Munster).
Sean Cronin will make his full Guinness Six Nations debut aged 32 and in his 68th cap when Ireland face Italy in Rome on Sunday.
Leinster's two-time Champions Cup-winning hooker already boasts Ireland's highest number of replacement appearances with 58 caps from the bench, and will earn just his 10th Test start this weekend.
Connacht fly-half Jack Carty could make his Test debut off the bench, with Joey Carbery nursing a suspected hamstring problem.
Ireland are close to the basement price to win here at 1/100, and they're asked to concede 29 points on Sky Bet's primary handicap line at 10/11 either way.
Italy can be backed at 16/1 to win and it's 50/1 the draw.
Click here to check out all Sky Bet's Italy v Ireland odds
Tony Calvin's verdict...
No bet.
Italy's forwards coach Giampiero De Carli...
"The loss of Sergio Parisse? It is clear that we lose one of the strongest number eights in the world, but we have players who are up to the situation that will be able to contribute to the team.
"We know Ireland well, we faced them last time in Chicago in the first Test match in November: it will be crucial for us to make the most of our opportunities."
Ireland's Jack Conan...
"I think the rest week gave us a good opportunity to go back to our basics, without having to focus on another side.
"Going up against England or Scotland, the whole week is trying to get your own detail sorted and then worrying about what they're doing.
"The off weeks are a chance to look inward and to try to improve what we're doing. I think there's been a lot of growth last week and even the start of this week.
"We're in a good spot and looking forward to a good day on Sunday."
2018: Ireland 54-7 Italy, USA
2018: Ireland 56-19 Italy, Dublin
2017: Italy 10-63 Ireland, Rome
2016: Ireland 58-15 Italy, Dublin
Round One (February 1-2)
Round Two (February 9-10)
Round Three (February 23-24)
Round Four (March 9-10)
Round Five (March 16)