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Hull welcome back captain Gareth Ellis and winger Steve Michaels from suspension for what will be their last appearances at the KCOM Stadium, while prop forward Liam Watts is free to play after being told he faces no further punishment for his dismissal in the defeat by Wigan.
Wakefield recall hooker Kyle Wood in place of Hull second rower Dean Hadley, who has been given a one-match ban but in any case is unable to face his parent club as part of the loan agreement. They have a major injury doubt over centre Reece Lyne, with Mason Caton-Brown standing by to step in.
This season's results: Wakefield 8 Hull 12, Hull 40 Wakefield 18.
Last six league matches: Hull L W W L L L Wakefield L L W L W L.
Top try scorers: Albert Kelly (Hull) 18; Ben Jones-Bishop (Wakefield) 19.
Top goal scorers: Marc Sneyd (Hull) 94; Liam Finn (Wakefield) 87.
Leeds welcome back hooker Rob Burrow from suspension while second rower Brett Ferres and stand-off Joel Moon have recovered from injury. Full-back Ashton Golding is recalled in place of Jack Walker, who has a hamstring injury.
Salford have forward George Griffin returning from injury and Dan Murray is also back in contention, while Jake Bibby continues to deputise for injured winger Greg Johnson.
This season's results: Leeds 20 Salford 14, Salford 24 Leeds 50.
Last six league matches: Leeds L W L W W L Salford L L L L W.
Top try scorers: Joel Moon & Matt Parcell (Leeds) 15; Ben Murdoch-Masila (Salford) 14.
Top goal scorers: Liam Sutcliffe (Leeds) 46; Gareth O'Brien (Salford) 48.
Referee: Liam Moore.
St Helens coach Justin Holbrook hands a recall to prop Kyle Amor in place of teenager Matty Lees while Jonny Lomax will switch from centre to stand-off if Ryan Morgan recovers from the head knock that forced to him to pull out of the game at Wakefield.
Huddersfield are set to draft in Tyler Dickinson and Daniel Smith to offset the loss of injured front rowers Shannon Wakeman and Sebastine Ikahihifo while half-back Sam Wood is also in the reckoning.
This season's results: St Helens 14 Huddersfield 14, Huddersfield 24 St Helens 16.
Last six league matches: St Helens W W L L L W Huddersfield L W L W L L.
Top try scorers: Mark Percival (St Helens) 14; Jermaine McGillvary (Huddersfield) 19.
Top goal scorers: Mark Percival (St Helens) 84; Danny Brough (Huddersfield) 60.
Referee: Gareth Hewer.
With promotion secured, Hull KR make wholesale changes, resting the likes of Shaun Lunt, Nick Scruton, Adam Quinlan and Thomas Minns. A side including academy international loose forward Brad Clavering will be captained by full-back Ben Cockayne in his final home game for the club.
Catalans are without skipper Remi Casty but have hooker Paul Aiton back from injury while former Hull KR threequarter Iain Thornley replaces winger Fouad Yaha. There is also a place in the 19-man squad for veteran utility back Thomas Bosc, who has announced his retirement from the end of the season.
Last season: No corresponding fixture.
Last six league matches: Hull KR L W W W W W Catalans Dragons L W L L W W.
Top try scorers: Ryan Shaw (Hull KR) 5; Brayden Wiliame (Catalans Dragons) 4.
Top goal scorers: Jamie Ellis (Hull KR) 21; Luke Walsh (Catalans Dragons) 15.
Referee: Robert Hicks.
Leigh have Ben Crooks, Ryan Hampshire and Matty Fleming all back in contention and vying to take the place of Matty Dawson, who loses his ever-present record.
Out of contention for the Million-Pound Game, Halifax coach Richard Marshall is set to give debuts to Jordan Syme, Frazer Morris and Will Calcott.
Last season: No corresponding fixture.
Last six league matches: Leigh W W L W L L Halifax W L L L L L.
Top try scorers: James Clare, Matty Dawson, Josh Drinkwater, Adam Higson, Liam Hood, Greg McNally, Daniel Mortimer, Cory Paterson & Atelea Vea (Leigh) 2.; Ben Heaton (Halifax) 6.
Top goal scorers: Josh Drinkwater (Leigh) 14; Steve Tyrer (Halifax) 5.
Referee: Chris Kendall.
Widnes are set to switch Danny Craven to full-back after Corey Thompson was ruled out with a head knock, with Tom Gilmore returning to partner Joe Mellor in the halves. Ed Chamberlain is poised to take over at centre from Chris Dean, who pulled a hamstring in the defeat at Hull KR, and hooker or half-back Jordan Johnstone is back in the frame.
London coach Andrew Henderson recalls former Wigan and Leigh prop Tom Spencer in the only change to the team that beat Halifax.
Last season: No corresponding fixture.
Last six league matches: Widnes L L W W W L London Broncos W L D L L W.
Top try scorers: Chris Bridge & Rhys Hanbury (Widnes) 4; Andy Ackers & Jarrod Sammut (London Broncos) 4.
Top goal scorers: Lloyd White (Widnes) 13; Jarrod Sammut (London Broncos).
Referee: James Child.
Wigan back rower Joel Tomkins is set to take over from skipper Sean O'Loughlin, who is out with a slight calf injury, while winger Joe Burgess has recovered from the hamstring problem that forced him to pull out of last week's win at Hull.
Castleford coach Daryl Powell has called up Tom Holmes and Jake Trueman in the absence of regular half-backs Luke Gale and Ben Roberts while Matt Cook, Oliver Holmes and Joel Monaghan help to plug the gaps caused by injury to Jy Hitchcox, Junior Moors, and Larne Patrick.
This season's results: Wigan 10 Castleford 27, Castleford 54 Wigan 4.
Last six league matches: Wigan W L W W W W Castleford W L W W W W.
Top try scorers: Liam Marshall (Wigan) 21; Greg Eden (Castleford) 37.
Top goal scorers: George Williams (Wigan) 41; Luke Gale (Castleford) 136.
Referee: Ben Thaler.
Featherstone have Ian Hardman and Richard Moore back from injury and Darrell Griffin has completed a two-match suspension. They take the places of Daniel Igbinedion, Jason Walton and Luke Briscoe, who has been given a one-match ban.
Warrington have hooker Daryl Clark, second rower Ben Currie and Ben Pomeroy returning from injury, while Jack Johnson and Morgan Smith are also back into the reckoning. They take the places of Joe Westerman, Benjamin Jullien, Declan Patton, Ben Westwood and Tom Lineham, who has an elbow injury.
Last season: No corresponding fixture.
Last six league matches: Featherstone L L D L L L Warrington W W W W W W.
Top try scorers: Luke Briscoe, John Davies, Kryan Johnson & Misi Taulapapa (Featherstone) 2; Peta Hiku (Warrington) 5.
Top goal scorers: Ian Hardman (Featherstone) 10; Declan Patton (Warrington) 23.
Referee: Scott Mikalauskas.