Aaron Rodgers produced a statistically perfect display as the Green Bay Packers battered the Oakland Raiders 42-24, while the San Francisco 49ers moved to 6-0 and the Baltimore Ravens caused an upset in Seattle.
Rodgers threw for 429 yards and five touchdowns, while also running one in himself as he achieved the perfect passer rating of 158.3. Rodgers also became the quickest QB to throw 350 touchdown passes as the Packers made a real statement.
The San Francisco 49ers continued their surprisingly unbeaten start to the season as they emerged with a scrappy 9-0 win at a rain-soaked Washington Redskins - with three Robbie Gould field goals doing the damage.
The Los Angeles Rams got back to winning ways in the NFL with a bad-tempered 37-10 success against the Atlanta Falcons.
Last season's NFC champions and beaten Super Bowl side had lost three in a row as they returned to the scene of that big game defeat at Mercedes Benz Stadium, but bounced back in style.
Jared Goff threw touchdown passes to Todd Gurley and Gerald Everett and ran in another score himself, while defensive back Darious Williams rounded off the scoring after a fumble by Falcons punt returner Kenjon Barner.
The Falcons had running back Devonta Freeman ejected for throwing a punch at Rams lineman Aaron Donald and lost quarterback Matt Ryan to an ankle injury after a sack by Donald. Replacement Matt Schaub hit Austin Hooper for their only touchdown.
NFC West rivals the Arizona Cardinals won 27-21 against the New York Giants, Chase Edmonds running for a career-best 126 yards and three touchdowns.
Lamar Jackson produced a superb running performance from quarterback to fire the Baltimore Ravens to a 30-16 victory against the Seahawks in Seattle - one of the toughest road trips there is in the NFL.
New Ravens signing Marcus Peters intercepted Russell Wilson for the first time this season and turned it into a pick six when taking it back for a touchdown on his debut.
Teddy Bridgewater continues to prove the New Orleans Saints can win without Drew Brees as he led them to a dominant 36-25 victory at the Chicago Bears - who only came close with to garbage time touchdowns.
The Minnesota Vikings beat NFC North rivals the Detroit Lions 42-30 despite four touchdown catches from the Lions' Marvin Jones. Dalvin Cook ran for two Vikings scores while Kirk Cousins threw touchdowns to four different receivers.
The Buffalo Bills moved to a 5-1 record with a 31-21 success against winless divisional rivals the Miami Dolphins.
Josh Allen threw touchdowns to John Brown and Cole Beasley and, after the Dolphins gave themselves hope, Micah Hyde crowned the win in unusual style by returning an onside kick for a touchdown.
The Indianapolis Colts moved top of the AFC South with a 30-23 win over the Houston Texans as Jacoby Brissett threw for 326 yards and four touchdowns, two of them to wide receiver Zach Pascal.
The Jacksonville Jaguars beat the winless Cincinnati Bengals 27-17, Yannick Ngakoue taking an ugly Andy Dalton pass back for a 23-yard interception score to seal the game.
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