A day of firsts in the Premier League as Wolves get a victory while Chelsea win at Stamford Bridge. Title-chasers Liverpool and Man City also had to work hard for victory.
We have all the details with a full round-up and match highlights for every game...
Premier League results
- Sheffield United 0-1 Liverpool - full report
- Aston Villa 2-2 Burnley
- Bournemouth 2-2 West Ham
- Chelsea 2-0 Brighton
- Crystal Palace 2-0 Norwich
- Tottenham 2-1 Southampton
- Wolves 2-0 Watford
- Everton 1-3 Manchester City - full report
Sheffield United 0-1 Liverpool
Liverpool extended their remarkable Premier League winning run to 16 successive matches but they needed a helping hand - literally - from Sheffield United goalkeeper Dean Henderson.
Having done an impressive job for 70 minutes of blunting a strikeforce which had scored 13 goals this season the on-loan Manchester United goalkeeper's blunder in allowing Georginio Wijnaldum's shot through his fingers was all the league leaders needed.
Liverpool's seven first-half shots were the most they had produced in the opening 45 minutes of a league match without one being on target since February 2017, when they lost to Hull.
Just when it seemed United were about to become only the only side after Barcelona and Napoli in the last 26 games to prevent the Reds scoring, Henderson blew it.
Wijnaldum's shot from the edge of the area was hit well but more in hope than expectation but, as it flew through a crowd of players, United's goalkeeper failed to get a proper hold and it slipped between his hands and then his legs to trickle over the line.
Nevertheless, substitute Leon Clarke should still have equalised five minutes from time but ballooned over Fleck's low cross from close range.
Liverpool's bandwagon rolls on, having taken an incredible 121 points from a last possible 138.
Everton 1-3 Man City
Riyad Mahrez and Raheem Sterling struck in the final 19 minutes as champions Manchester City claimed a hard-fought 3-1 win over spirited Everton.
Gabriel Jesus put City ahead at Goodison Park but the hosts did not look like a side that had lost three of their last four Premier League games and hit back through Dominic Calvert-Lewin.
Both sides then had further chances but it was City who secured the points after Mahrez beat Jordan Pickford with a low free-kick and Sterling struck via the woodwork.
The result ensured City remained five points behind leaders Liverpool, a relief after a difficult week.
Aston Villa 2-2 Burnley
Chris Wood headed home a late equaliser as Burnley twice came from behind to deny Aston Villa a second Premier League win of the season.
The hosts, who also led twice at Arsenal last week before succumbing to defeat, thought they were heading for a vital three points when John McGinn scored his third of the season in the closing stages - only for Wood to level moments later to secure a 2-2 draw for Sean Dyche's side.
Anwar El Ghazi had given Villa the half-time lead after McGinn had earlier seen an effort chalked off by the video assistant referee, with Burnley substitute Jay Rodriguez equalising with his first Premier League goal since April 2018.
Villa remain in the bottom three having once again lost points from a winning position - the third time the newly-promoted side have done so since returning to the top-flight.
Villa thought they were ahead on 25 minutes as Hourihane and Jack Grealish exchanged passes, with the former's low cross missed by Wesley but tucked away by McGinn from close-range.
The home fans were still celebrating as referee Lee Mason took the ball from the centre-spot and signalled the goal had been ruled out by VAR with Hourihane offside in the build-up.
Just eight minutes later and Villa could legitimately celebrate taking the lead as a raking pass found Frederic Guilbert, who burst forward before crossing in for El Ghazi to steer a finish past Nick Pope.
The goal gave Villa added impetus and they ended the first-half well on top, El Ghazi heading over before Grealish forced a smart save out of Pope.
Rodriguez came on at the interval for the visitors, who looked lively from the outset as Jeff Hendrick whistled a shot over the crossbar.
With Dyche's men dominating play and following a slight delay as Villa striker Wesley required treatment and Targett limped off injured, Rodriguez headed the visitors level from a Pieters cross.
That seemed to spur Villa back into action, Grealish arrowing a strike over the bar as Smith's side went in search of the lead once more.
Wesley then thought he was breaking through on Pope's goal only for Mee to make a last-gasp lunge and get just enough pace on the ball for the Burnley goalkeeper to clear.
Villa would regain their advantage with 11 minutes left on the clock, McGinn's measured left-foot finish going under Pope to seemingly put the hosts on course for a second league win of the season.
But it was not to be as Burnley would equalise for the second time just two minutes later, Wood playing the ball out wide to Matthew Lowton before getting on the end of a deflected cross to head in from six yards.
Bournemouth 2-2 West Ham
VAR was at the centre of the action and the controversy at Dean Court, as Bournemouth and West Ham shared the points.
West Ham climbed to third in the Premier League after Aaron Cresswell's 74th-minute equaliser earned a 2-2 draw.
Joshua King's goal, which was initially ruled out for offside before the decision was overturned by a VAR, and Callum Wilson's fifth strike in four games put the Cherries on course for victory at the Vitality Stadium after Andriy Yarmolenko's early opener.
But left-back Cresswell extended the high-flying Hammers' unbeaten run to six top-flight games by firing home via a deflection off Steve Cook.
The visitors, who lost goalkeeper Lukasz Fabianski to a first-half injury, move a point behind second-placed champions Manchester City.
Eddie Howe's Cherries, a point further back, had a Nathan Ake effort chalked off for offside against team-mate Dominic Solanke at 2-1, while England striker Wilson wasted a golden chance to put the game beyond West Ham.
In-form winger Yarmolenko put the away side ahead inside 10 minutes with his third goal in four games.
The Ukrainian twisted away from Dutchman Ake in the box to curl into the left corner after Sebastien Haller superbly brought down Felipe Anderson's diagonal pass into the box and laid the ball back.
Bournemouth forward King was denied a goal by VAR due to a marginal offside decision during last Friday's victory over local rivals Saints. The technology worked in his favour on this occasion.
Assistant referee Constantine Hatzidakis raised his flag after King fired home from inside the six-yard box but, during a lengthy delay, replays showed the Norwegian was clearly onside following Diego Rico's hopeful ball forward and Ake's inadvertent knockdown.
The goals came from two of only three efforts on target in an open and evenly-matched first half.
Bournemouth made the most their next opportunity by edging in front around 30 seconds into the second period.
Wilson calmly converted into the bottom left corner after the ball broke to him just inside the 18-yard box to claim his seventh goal in as many games against the Hammers.
Defender Ake was then denied a third after his deflected drive following a corner was ruled out for Solanke's infringement, with the decision of assistant referee Nicholas Hopton supported by VAR.
After Wilson wasted a golden chance to make it 3-1 by firing straight at Roberto when through on goal, the visitors levelled with 16 minutes to go.
Chelsea 2-0 Brighton
Frank Lampard got his first Premier League home win as Chelsea boss as second-half goals from Jorginho and Willian sank Brighton 2-0.
The Blues had peppered the Brighton goal throughout the first half but only made the breakthrough when Jorginho tucked in a penalty five minutes after half-time.
Willian's well-taken second secured a maiden three points at home for Lampard, while Brighton never really threatened to deny the hosts a first clean sheet of the season.
For the Seagulls, the Graham Potter revolution has yet to take off and they have now not won since the opening weekend of the season, and they ma managed just one shot on goal in this one, in stoppage time.
Chelsea, by contrast, had 17 shots - three of them sitters - in a one-sided first half without finding a way through.
They were inches away from taking the lead when Tammy Abraham glanced a header which bounced against a post.
😀He's been made to wait, but Frank Lampard finally has his first Stamford Bridge Premier League victory as @ChelseaFC boss
— Sporting Life Football (@SportingLifeFC) September 28, 2019
Congratulations Frank#CFC pic.twitter.com/4D2m0tS5TG
Brighton somehow survived the first half, but five minutes into the second Adam Webster hit the self-destruct button.
Webster's poor touch in the area allowed Mason Mount to poke the ball away from him, and as the defender tried to win it back he tripped the youngster.
Jorginho assumed penalty-taking duties despite Pedro notching one against Grimsby in midweek, and the Italian coolly rolled it home.
Brighton briefly threatened an equaliser, Steven Alzate seeing a shot deflected wide before Dan Burn headed the resulting corner into the ground and up off the crossbar.
But their rally was short-lived, Callum Hudson-Odoi feeding Willian who charged into the box and finished at the near post.
Crystal Palace 2-0 Norwich
Luka Milivojevic's first-half penalty and a late strike by Andros Townsend was enough to give Crystal Palace a third win of the season and inflict more away pain on Norwich.
The Canaries had chances in the opening 45 minutes at Selhurst Park, but failed to take them and struggled to create after the break as Palace ran out 2-0 winners.
It saw the promoted visitors leave London with another defeat - making it five in a row on the road this season - and more injuries to add to an already hefty list.
Roy Hodgson would have pleased with his players after they conceded late in the 1-1 draw at home to Wolves last weekend and they are now unbeaten in their last six games at Selhurst Park following this win.
The Canaries' German stopper Ralf Fahrmann had not been tested much during the opening exchanges, but had to pick the ball out of his net in the 21st minute.
Zaha was involved once more, turning Cantwell and although his cross failed to pick out a team-mate, McArthur got to the loose ball ahead of Ibrahim Amadou and won his team a spot-kick.
Milivojevic made no mistake from 12 yards, curling into the top corner and Norwich's pain increased when Fahrmann, only just back from a groin injury, needed to be replaced by Michael McGovern, who was making his first league appearance since April 2017.
Daniel Farke's men did regroup admirably and top goalscorer Teemu Pukki had his first shot in the 29th minute, but Vicente Guaita was able to tip over.
Aware they needed a second, Hodgson's side had more purpose about their play at the start of the second half and McArthur got into a number of promising positions.
The visitors made a second change in the 66th minute with Marco Stiepermann replaced by Josip Drmic before Palace responded with Townsend on for Cheikhou Kouyate four minutes later.
Eventually the second arrived for Palace and Zaha was at the heart of it, wriggling away from his marker before finding Townsend and he curled into the corner in the second minute of stoppage time to wrap up a 2-0 win.
Tottenham 2-1 Southampton
Tottenham put a bad week behind them as they earned only their third Premier League win of the season, beating Southampton, despite Serge Aurier's first half sending off and a Hugo Lloris clanger.
Boss Mauricio Pochettino said it would take time to find unity in his squad after a turbulent summer where several players either wanted to leave or thought they were leaving, but they showed promising signs in a rearguard effort.
Tanguy Ndombele's goal put them in front early on, but after Serge Aurier was sent off just after the half-hour a calamitous error from Lloris gifted Southampton an equaliser through Danny Ings.
But Harry Kane came to the rescue as he scored a fine team goal, his fifth in the Premier League, to hand Spurs the three points that will go a long way to lifting the gloom at the club.
It was their third win of the season and Pochettino will hope that they can move forward ahead of Tuesday's Champions League clash with Bayern Munich.
Southampton enjoyed a spell of pressure early in the second half, but they did not really threaten an equaliser and slipped to a third defeat of the season.
Just once Spurs would like to do things the easy way and a straightforward afternoon looked a possibility after they enjoyed a promising opening 30 minutes.
After Lloris had thwarted early danger from Pierre-Emile Hojbjerg, with a smart stretching save, the home side - and specifically Ndombele - came to life.
After seeing one goalbound effort deflected, he was rewarded with the opener in the 24th minute.
Spurs recycled an attack, the ball fell to Son Heung-min and he teed up Ndombele to lash home an effort that went through Angus Gunn's grasp.
Any hopes of kicking on from there were abruptly ended in the space of four minutes as Aurier picked up two yellow cards for brainless fouls and was sent off in the 31st minute.
The last thing Spurs needed to do was give Southampton a helping hand, but that is what happened after an unforgivable piece of play from Lloris.
The Frenchman has a reputation for being a liability in possession - not something you want from a goalkeeper whose side play out from the back - and his error gifted the Saints the equaliser in the 39th minute.
Receiving the ball inside his own six-yard box, Lloris inexplicably tried a Cruyff turn with Ings closing in on him, but missed his kick and the Southampton striker's tackle saw the ball dribble over the line.
It was Lloris' ninth error leading to a goal in just over three years and surely his worst.
Given all the negativity surrounding the club this season it could have been easy for Spurs to sink, but it took them only four minutes to regain their lead.
In a move that started off with Moussa Sissoko, it took just 11 touches for the ball to end up in the back of the net as Kane flicked on a long ball, Son and Christian Eriksen exchanged passes, with the Dane then setting up the England captain to fire into the bottom corner.
Lloris was in negative equity after his first-half gaffe but went some way to getting back into credit with a couple of excellent stops after the restart.
First he tipped a curling James Ward-Prowse free-kick out with a flying save and then did even better to beat away Maya Yoshida's free header.
Wolves 2-0 Watford
It was seventh time lucky for Wolves, as they finally recorded their first Premier League victory of the season, seeing off struggling Watford who are still looking for their's.
Matt Doherty's strike and a Daryl Janmaat own goal ensured it was Nuno Espirito Santo's side who broke their duck with a 2-0 success and climbed out of the bottom three, while the Hornets remain at the foot of the table.
The action was frenetic and end-to-end in the opening stages as both tried to begin on the front foot.
Danny Welbeck, making his first Premier League start for Watford, threatened for the visitors before Raul Jimenez drove a shot into the side-netting for Wolves and flashed another effort narrowly wide.
Watford were wasteful in the final third and looked fragile at the other end, so it was little surprise when the hosts went ahead after 18 minutes.
Good link up play involving Joao Moutinho, Jonny and then Pedro Neto - making his first Premier League start for the club - saw the debutant find Doherty's run with a brilliant low cross and the full-back tapped the ball home.
Watford were having plenty of possession without really troubling Wolves, who doubled their lead just after the hour mark. Doherty was involved again, he crossed the ball into the penalty area where it was flicked on by Morgan Gibbs-White and went into the net off the unlucky Daryl Janmaat.
The Hornets came from two goals down to earn a draw against Arsenal this month in Quique Sanchez Flores' first game back as manager and had Patricio not produced a fine save to deny Welbeck after 72 minutes, then they might have thought a repeat was on the cards.
