Michael O'Neill has been sacked by Stoke after three years in charge, becoming the first Sky Bet Championship manager to lose his job this season.
“Michael joined us in November 2019 when the club was in a difficult situation and the job he did in stabilising our position in the Championship should not be underestimated," said joint chairman John Coates.
“Michael has worked tirelessly and with extreme professionalism, in particular in reshaping our squad and developing young players, but we feel the time is right to move in a different direction. I would like to thank him for his efforts and wish him every success for the future.”
Assistant manager and former Bristol City boss Dean Holden has been placed in interim charge.
Stoke travel to Blackburn in the Championship on Saturday.