Two Euro giants meet at the Bernabeu as Real Madrid welcome Paris Saint-Germain in Group A, while Group D leaders Juve are at home to Atletico.
Shakhtar the visitors to the Etihad as Pep Guardiola's Man City will look to extend their unbeaten start to the European campaign and Jose Mourinho takes charge of his first Champions League game as Spurs boss when Olympiakos travel to north London.
All games in this offer are due to get underway at 2000 GMT (November 26).
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Jose Mourinho celebrates his first win as Tottenham boss - click here to check out the latest Sporting Life Price Boost involving the Portuguese's new side
Juventus can make home advantage count against Atletico Madrid on Tuesday night, according to Paul Higham - he previews the opening night of matchday five in the Champions League.
Check out Tuesday's Champions League preview and best bets
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