A round-up of Saturday's action in the top flight...
Aleksandar Mitrovic scored twice as Claudio Ranieri won his first match as Fulham boss to pile pressure on Southampton manager Mark Hughes.
Stuart Armstrong netted a brace - his first Saints goals - either side of strikes from Mitrovic and Andre Schurrle for Fulham.
Mitrovic, who rivalled Armstrong as the game's star performer, restored the hosts' lead with a crisp volley after 63 minutes and Fulham held on to win 3-2 on Ranieri's Premier League return.
The Cottagers were facing the prospect of a seven-match losing streak in the league for the first time in 56 years, but instead they won for a second time this season, following the August 26 defeat of Burnley, to move off the foot of the table.
Southampton have not won since September 1 against Crystal Palace and Hughes, who had an 11-month stint at Craven Cottage in 2010-11, has just three wins in 21 league games since his appointment in March.
Manchester City found the London Stadium to their liking again as they thumped West Ham 4-0.
Strikes from David Silva, Raheem Sterling and Leroy Sane's double took City's tally to 17 goals in only four visits to Stratford.
An ultimately routine victory made it eight wins from eight in all competitions and strengthened City's hold on top spot in the Premier League.
Roberto Firmino ended his Premier League goal drought as 10-man Liverpool maintained their unbeaten start at Watford.
The striker headed in late on to complete a 3-0 win and score his first top flight goal since September 15.
Trent Alexander-Arnold's brilliant free-kick had made it 2-0 after Mohamed Salah opened the scoring after the break.
But Liverpool will be without Jordan Henderson for next weekend's Merseyside derby with Everton after he was sent off for two bookings.
Hard-working Watford will feel aggrieved after Jon Moss rejected their penalty claims when Andy Robertson tripped Will Hughes in the second half with the score level.
It was far from a vintage Liverpool performance but they remain unbeaten in 13 games and two points behind Premier League leaders Manchester City.
👊👏 Spurs end Chelsea's unbeaten run in style with a 3-1 victory at Wembley!
— Sporting Life Football (@SportingLifeFC) November 24, 2018
⚽️ Dele Alli's 6th goal in his last 5 v #CFC
⚽️ Harry Kane's 25th #EPL London derby goal
⚽️ Son Heung-min's 50th #THFC goal
⚪️ Spurs are just five points behind #MCFC#TOTCHE pic.twitter.com/BezOjbIU1D
Chelsea tasted defeat in the Premier League for the first time this season, as they were stunned with a 3-1 scoreline at Tottenham.
Mauricio Pochettino's side leapfrog them to go third in the process, after goals from Dele Alli, Harry Kane and Heung-min Son.
Click here for the full report and Opta stats...
Everton climbed to sixth place in the Premier League table after battling to a 1-0 victory over Cardiff at Goodison Park.
The visitors made life difficult for the Toffees but Marco Silva's side ultimately deserved the win given to them by Gylfi Sigurdsson's 59th-minute goal, securing a fourth consecutive home success.
Jamie Vardy came off the bench to rescue a point for 10-man Leicester as they battled back to draw at Brighton.
The forward was only deemed fit enough to be named as a substitute for the Foxes following a groin injury, but he fired home a second-half penalty to cancel out Glenn Murray's early header and secure a 1-1 draw.
Leicester's hopes of taking anything away from the Amex Stadium took a hit when James Maddison was sent off inside the opening half-an-hour.
The midfielder was cautioned twice in two minutes, having overcome a knee problem to start for Claude Puel's side, who have now had four dismissals in the league this season.
Murray's 15th-minute header was his seventh league goal of the campaign, bringing him level with the likes of Pierre-Emerick Aubameyang and Raheem Sterling, but the Seagulls created little as they failed to make their numerical advantage pay.
Manchester United stuttered to an uninspiring goalless draw at home to struggling Crystal Palace as Jose Mourinho's disjointed side fell further behind the leading pack.
Boos greeted the final whistle at Old Trafford, such was the home side's listless performance against a side without a Premier League win for 10 weeks.
Roy Hodgson's men threatened to leave United with all three points for the first time since 1989, but Palace had to make do with a 0-0 as the hosts failed to get the win they desperately needed to kick-start their campaign.
Mourinho's men are now an eye-watering 14 points behind table-topping Manchester City and, more worryingly, let this great chance to reduce the gap to the top four pass.
United were tepid against a Palace side whose performance belied their lowly standing, with Wilfried Zaha tormenting his former club and Cheikhou Kouyate seeing a goal ruled out for offside on an afternoon when Patrick Van Aanholt and Andros Townsend wasted glorious chances.
Chris Smalling missed his own gilt-edged chance and Romelu Lukaku saw a goal disallowed for offside, but it was not a performance that satisfied the Old Trafford faithful. Ineffective Paul Pogba's substitution was greeted warmly and groans turned to loud jeers at full-time.