Netherlands v Germany (1945 BST)
The merits of this tournament really show with his fixture between these two European superpowers in a group that also contains World Cup winners France.
The Germans endured a shocking campaign in Russia this summer but Joachim Low has kept his job and continues the rebuilding process after a 0-0 draw with the French in their opening Nations League game.
Ronald Koeman has an even bigger rebuilding job on with the Dutch, who failed to make the World Cup and lost their Nations League opener against France 2-1.
Dutch fans believe they’re on the up with Koeman and Amsterdam will provide solid home advantage, and there have been a few late withdrawals from the German squad to just upset Low’s plans somewhat.
Leroy Sane being back in the squad should give Germany a much-needed burst of pace, as long as he plays, but there still seems to be problems withi the Germany set up and it's a great time for the Dutch to get a vital confidence-boosting victory.
Prediction: Netherlands 2-1 Germany (Sky Bet odds: 11/1)
Best bet: Netherland to win at 11/5
Republic of Ireland v Denmark (1945 BST)
This fixture holds some harsh memories for the Irish after Denmark's emphatic 5-1 World Cup play-off victory, although the expected absence of Christian Eriksen could be a massive boost for the hosts.
Eriksen scored a hat-trick in that World Cup play-off, and also bagged both goals in Denmark's 2-0 win over Wales in their opening Nations League game. The Spurs man has 15 goals in his last 17 competitive games for his country.
Martin O'Neill's side may not have Eriksen to worry about but there's a host of other problems to deal with as Seamus Coleman, Jonathan Walters, Robbie Brady and Stephen Ward all miss out.
There's also the distinct lack of goals and the Harry Arter situation - he returns after missing last month's games against Wales and Poland following a bust-up with assistant manager Roy Keane.
There's no doubt Denmark and completely different prospect with Eriksen than without him and this should be a huge opportunity for the hosts - but that lack of goals is a worry, a big worry in fact so this one has all the right ingredients of a low-scoring draw.
Prediction: Rep of Ireland 1-1 Denmark (Sky Bet odds: 5/1)
Best bet: Draw at 2/1
Slovakia v Czech Republic (1400 BST)
Slovakia look a decent bet given their decent home record of just one defeat in ten against a Czech Republic side that has lost three of their last four.
Two of those defeats have been heavy losses for the Czech's and there's plenty of experience and guile in the Slovakian side to be able to pray on any remaining frailties from those defeats.
Both teams lost to Ukraine in their opening games so it's a crucial contest for both of them
Prediction Slovakia 2-1 Czech Republic (Sky Bet odds: 17/2)
Best Bet: Slovakia to win and both teams to score at 4/1
Odds correct at 1915 BST (12/10/18)
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