On an evening that saw Tom Lockyer return to the Vitality Stadium to thank the medical staff who had helped to save his life 88 days earlier, when this fixture was abandoned after the Luton captain suffered a cardiac arrest, the hosts’ rousing response put a huge dent in the Hatters’ survival hopes.
Luton raced into a commanding lead at half-time before a dramatic second-half showing from Andoni Iraola’s side saw them become the fifth team in Premier League history to win after trailing by three goals.
The visitors opened the scoring in the ninth minute after Jordan Clark stood up a sumptuous cross for Tahith Chong to head in at the far post.
Bournemouth sought an immediate response and Ryan Christie and Luis Sinisterra both went close to scoring but saw their efforts blocked by Thomas Kaminski.
Iraola’s side had gone two goals behind against bottom club Sheffield United at the weekend before fighting back to earn a point in stoppage time.
They found themselves in a similar position when Luton scored a brilliant second goal after 31 minutes.
It came after an incisive one-two between Chong and Alfie Doughty, before the latter crossed low to Chiedozie Ogbene, who rounded off a superb team move.
Edwards must surely have thought his team had sealed their third away win of the season when Issa Kabore drove upfield to pick out the excellent Ross Barkley, who powerfully fired the ball high into the net to give the Hatters a considerable cushion going into the break.
But after making two substitutions during the interval, Bournemouth hit back dramatically, scoring three times in 14 minutes at the start of the second half.
The first was a stunning piece of individual brilliance from top scorer Dominic Solanke. The Cherries striker back-heeled the ball between the legs of Daiki Hashioka before chipping it beyond Kaminski.
The second came after Luton were unable to clear Lewis Cook’s corner to safety and Illia Zabarnyi headed in from close range despite Doughty’s desperate attempts to prevent it crossing the line.
Two minutes later the Vitality Stadium erupted when Semenyo cut in from the right and fired his shot powerfully into the near post to level the scores.
Bournemouth were not done there and claimed all three points when Semenyo scored his second seven minutes from time, collecting the ball from Enes Unal before shooting powerfully across Kaminski to give the Cherries their first home win since Boxing Day.