George Pitts looks ahead to Saturday's early kick-off, as West Ham look to go four unbeaten in all competitions.
1pt Draw no bet - West Ham at 9/4
1pt Marko Arnautovic and Romelu Lukaku both to score at 5/1
For details of advised bookmakers and each-way terms, visit our transparent tipping record
The meeting of two sides who suffered very different fortunes in the Carabao Cup in midweek.
West Ham extended their unbeaten run to four matches in all competitions as they hit eight without reply against Macclesfield on Wednesday - their biggest win in any competition since October 1983 - while Man United lost to Frank Lampard's Derby on penalties at Old Trafford.
Jose Mourinho's fallout with Paul Pogba then dominated the headlines to plunge the manager's future at the club into further doubt.
The Portuguese is the favourite with Sky Bet to be the next Premier League manager to leave. While that is highly unlikely in the next few days, the 55-year-old could really do with a win on Saturday.
They face a tough trip to the London Stadium, where Chelsea were held to a goalless draw last weekend. While Manuel Pellegrini's side did well to halt Maurizo Sarri's Chelsea, they missed star man Marko Arnautovic going forward and the Austrian could return for the visit of the Red Devils - a timely boost for the Hammers.
Score prediction: West Ham 2-1 Man United (Sky Bet odds: 14/1)
It's difficult to call, relying on whether Jose Mourinho gets a reaction out of his Red Devils side or if the off-field fallouts will disrupt them further, as well as which West Ham side will turn up.
Should Arnautovic return as expected, he could prove vital in the final third and West Ham have plenty of reasons to be confident after holding Chelsea to a draw at the same ground six days earlier.
Best bet: Draw no bet - West Ham at 9/4
Considering a West Ham victory is available at a best price of 7/2, backing the hosts in a draw no bet at just over 2/1 offers you great value still with added insurance.
United could be vulnerable and less likely to take chances with the current talk once again surrounding Mourinho, while Pellegrini's men will take confidence from last week's draw and could make things go from bad to worse for the Red Devils.
Goalscorer bet: Marko Arnautovic and Romelu Lukaku both to score at 5/1
You can back either Arnautovic and Lukaku anytime at a best price of 13/5 and 13/10, but combining them returns good odds.
Arnautovic is the Hammers' danger man, the player they look to for inspiration and a moment of magic, while Lukaku has scored against West Ham more than any other club. The Belgian has found the back of the net against the east Londoners 11 times in 10 appearances, assisting four more goals.
Home fans will not be so pleased to see the 25-year-old lining up at the London Stadium.
There was no goalscorer in West Ham's last time at home against top opposition, and an 11/1 best price is worth a mention.
RequestABet: Arnautovic & Lukaku to score, over 2.5 goals and 50+ match booking points at 20/1
Odds correct as of 1200 BST 27/09/18