Our guide to Saturday's Guinness Six Nations clash between Ireland and Scotland in Dublin includes team news, predictions, statistics and more.
The match, which takes place at the Aviva Stadium in Dublin, will start at 1645 GMT on Saturday February 1 and will be screened live on ITV.
Ireland team: Larmour; Conway, Ringrose, Aki, Stockdale; Sexton, Murray; Healy, Herring, Furlong; Henderson, Ryan; Stander, van der Flier, Doris.
Replacements: Kelleher, Kilcoyne, Porter, Toner, O'Mahony, Cooney, Byrne, Henshaw.
Scotland team: Hogg; Maitland, Jones, Johnson, Kinghorn, Hastings, Price; Sutherland, Brown, Fagerson, Cummings, Gray, Ritchie, Watson, Haining.
Replacements: McInally, Dell, Berghan, Toolis, Du Preez, Horne, Hutchinson, Harris.
England begin their Six Nations quest with a tough away fixture which they are 1/10 to win. Scotland, 11/2 for victory, are a 13-point handicap start by Sky Bet.
Tony Calvin preview: I am not going mad on the stakes front here, as Ireland hardly come in on the crest of a wave, but it is the home side on the general -13 handicap (evens with Betfair) for me.
Ireland captain Johnny Sexton admits to being unsure how the absence of influential stand-off Finn Russell will affect opponents Scotland during Saturday's Guinness Six Nations opener.
Russell will not be involved at the Aviva Stadium after being disciplined for breaching team rules, with Adam Hastings selected as his replacement.
"It's like for like really. When you talk about Finn Russell's strengths, you're talking about Adam Hastings' strengths, they're all the same," said Sexton.
"I don't know how it will disrupt them, they've sort of played it down a little bit.
"They seem to be happy with where they're at and he (Hastings) is a quality player and one that we are going to have to be fully switched on for because he has a full bag of tricks that he can pull out."
Fly-half Sexton has not played since suffering a knee injury playing for Leinster in early December but insists he is "raring to go" following a training camp in Portugal.
"Yeah, great. No setbacks really to talk about," said the 34-year-old.
"It felt good on Thursday in Portugal and I've done pretty much everything since, so delighted to be fit and raring to go now."
"I don't know if we have a point to prove. What I can say is that the team have prepared really well, the intensity levels and communication in training have been excellent.
"Things have gone well, but we know mindset has a big part to play in high-level sport.
"We have to be focused, confident and prepared to do the tough stuff at the weekend.
"It's a new team. We know the performance in Yokohama wasn't anywhere near good enough but this is a new team. The players are looking forward rather than back."
"It's important we are in the game and we stay in the fight for as long as possible. We are looking to impose our game on Ireland but we know that won't be easy.
"When you play a team like Ireland, who have so much quality and they are on their own patch, it's pretty clear they will bring their own energy and their own game.
"The first 20-30 minutes will be tough and we need to be up for that, we need to enjoy the defensive side of the game.
"Ireland, out of all the teams in world rugby, make you tackle the most. There will be high tackle numbers.
"It may change with a new coach, but we don't think so, we think the formula will be the along similar lines. They have selected an experienced squad."
2016 Six Nations: Ireland 35-25 (Dublin)
2017 Six Nations: Scotland 27-22 Ireland (Murrayfield)
2018 Six Nations: Ireland 28-8 Scotland (Dublin)
2019 Six Nations: Scotland 13-22 Ireland (Murrayfield)
2020 World Cup: Ireland 27-3 Scotland (Japan)
Round One (February 1-2)
Round Two (February 8-9)
Round Three (February 22-23)
Round Four (March 7-8)
Round Five (March 14)