Former Brighton boss Graham Potter is odds-on favourite to return to the Premier League club.
It comes after previous favourite, Francesco Farioli, opted to accept the Ajax job.
De Zerbi departed by mutual consent after his Seagulls side finished the season with a 2-0 defeat against Manchester United.
Potter enjoyed a solid three-year spell at Brighton, transforming them from relegation candidates to a top-half finish before leaving to take up the Chelsea position in September 2022.
Next Brighton manager odds (via Sky Bet)
- Graham Potter - 4/6
- Kieran McKenna - 4/1
- Russell Martin - 8/1
- Henrik Rydstrom - 10/1
- Liam Rosenior - 10/1
Odds correct at 1515 BST (29/05/24)
Safer gambling
We are committed in our support of safer gambling. Recommended bets are advised to over-18s and we strongly encourage readers to wager only what they can afford to lose.
If you are concerned about your gambling, please call the National Gambling Helpline / GamCare on 0808 8020 133.
Further support and information can be found at begambleaware.org and gamblingtherapy.org.