No European men's side has ever won back-to-back trebles. Egyptian team Al Ahly and New Zealand side Auckland City are the only top-flight clubs to do so anywhere across the globe.
Manchester City are now 5/1 to do the seemingly impossible.
And it's very difficult to back against them, with Pep Guardiola's side unbeaten in 27 matches in all competitions, winning 22, stretching back to a December 6 defeat at Aston Villa - their only loss since October 8.
A pivotal Sunday in the title race saw Liverpool beaten at home by Crystal Palace before Arsenal lost to Aston Villa at The Emirates, results which saw City cut into cut into 4/9 favouritism and left them two points clear at the top with six games to play.
If they go on to retain just the Premier League, it would be the first time in the history of English football that a team has won four straight top division titles.
Huddersfield, Arsenal, Liverpool and Manchester United are the only other sides to win three in a row.
Man City are 6/4 favourites for the Champions League with their quarter-final tie against Real Madrid sitting at 3-3 after a classic at the Bernabeu.
En route to winning the crown for the very first time last season, Guardiola's side thrashed Madrid 4-0 at The Etihad.
Should they progress, Arsenal or Bayern Munich await in the semi-finals.
On the other side of the draw Barcelona take a 3-2 lead into their home leg with PSG and Dortmund will look to overturn a 2-1 deficit at home to Atletico Madrid.
City are 4/7 favourites to win the world's oldest knockout competition.
They take on Chelsea in the last four with Manchester United and Coventry contesting the other semi-final.
Odds correct at 1000 GMT (15/04/24)
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